GENETIC-MAPPING OF A 2ND LOCUS PREDISPOSING TO HEREDITARY NONPOLYPOSIS COLON-CANCER

被引：405

作者：

LINDBLOM, A

TANNERGARD, P

WERELIUS, B

NORDENSKJOLD, M

机构：

[1] Department of Clinical Genetics, Karolinska Hospital, Stockholm

来源：

NATURE GENETICS | 1993年 / 5卷 / 03期

关键词：

D O I：

10.1038/ng1193-279

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hereditary colon cancer is caused by mutations in several different loci. The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer. One gene causing HNPCC was recently mapped to chromosome 2 but the same study also showed that at least one additional locus may cause HNPCC. We now present tight linkage between a polymorphic marker on the short arm of chromosome 3 and the disease locus, and find that these families also manifest signs of a general DNA replication disorder.

引用

页码：279 / 282

页数：4

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