IMMEDIATE EFFECTS OF 14 NON MAOI ANTIDEPRESSANTS IN RATS WITH SPONTANEOUS PETIT MAL-LIKE SEIZURES

被引：10

作者：

WARTER, JM ^{[1
]}

TRANCHANT, C ^{[1
]}

MARESCAUX, C ^{[1
]}

DEPAULIS, A ^{[1
]}

LANNES, B ^{[1
]}

VERGNES, M ^{[1
]}

机构：

[1] CNRS,CTR NEUROCHIM,STRASBOURG,FRANCE

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1990年 / 14卷 / 02期

关键词：

antidepressants; petit mal epilepsy; rat epilepsy model;

D O I：

10.1016/0278-5846(90)90106-Q

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Wistar rats of a strain presenting spontaneous petit mal-like seizures were injected intraperitoneally with graded doses of 14 non-monoamine oxidase inhibitor antidepressants and the immediate effects on behavior and the EEG were recorded. 2. Amineptine and nomifensine, the two drugs interacting with dopaminergic neurotransmission, reduced the duration of spontaneous spike-wave discharges (SWD) and were thus potentially antiepileptic. 3. Trazodone increased SWD duration. 4. The antidepressants, imipramine-like (imipramine, chlorimipramine, desipramine, metapramine and amitriptyline) and non-imipraminic (minaprine, maprotiline, viloxazine, mianserin, fluvoxamine and indalpine), and the 3 noted above, had potentially convulsive effects. © 1990.

引用

页码：261 / 270

页数：10