Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease?

被引：8

作者：

Williams, Gareth ^{[1
]}

Shi-Wen, Xu ^{[2
]}

Abraham, David ^{[2
]}

Selvakumar, Sadasivam ^{[3
]}

Baker, Daryll M. ^{[1
]}

Tsui, Janice C. S. ^{[1
]}

机构：

[1] UCL, Div Surg Intervent Sci, Royal Free Campus, London NW3 2QG, England

[2] UCL, Ctr Rheumatol Connect Tissue Dis, London NW3 2QG, England

[3] Lister Hosp, Dept Surg, Stevenage SG1 4AB, Herts, England

来源：

CARDIOLOGY RESEARCH AND PRACTICE | 2012年 / 2012卷

关键词：

D O I：

10.1155/2012/656247

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral Arterial Disease (PAD) is a cause of significant morbidity and mortality in the Western world. Risk factor modification and endovascular and surgical revascularisation are the main treatment options at present. However, a significant number of patients still require major amputation. There is evidence that nitric oxide (NO) and its endogenous inhibitor asymmetric dimethylarginine (ADMA) play significant roles in the pathophysiology of PAD. This paper reviews experimental work implicating the ADMA-DDAH-NO pathway in PAD, focussing on both the vascular dysfunction and effects within the ischaemic muscle, and examines the potential of manipulating this pathway as a novel adjunct therapy in PAD.

引用

页数：7

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