THE ROLES OF DROSOPHILA CYCLIN-A AND CYCLIN-B IN MITOTIC CONTROL

被引：430

作者：

LEHNER, CF ^{[1
]}

OFARRELL, PH ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143

来源：

CELL | 1990年 / 61卷 / 03期

关键词：

D O I：

10.1016/0092-8674(90)90535-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned, sequenced, and characterized the expression of a Drosophila cyclin B gene. The independent evolutionary conservation of A- and B-type cyclins implies that they have distinct roles. Indeed, in mutant embryos deficient in cyclin A, cells that accumulate only cyclin B do not enter mitosis. Thus, in vivo, cyclin B is not sufficient for mitosis. Furthermore, we find that the two cyclins are coexpressed in all proliferating cells throughout development. Though lacking a formal demonstration that cyclin B is essential as it is in other organisms, we propose that each of these proteins fulfills a distinct and essential role in the cell cycle. © 1990.

引用

页码：535 / 547

页数：13

共 48 条

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