SLOW GLUCOSE REMOVAL RATE AND HYPERINSULINEMIA PRECEDE THE DEVELOPMENT OF TYPE-II DIABETES IN THE OFFSPRING OF DIABETIC PARENTS

被引：889

作者：

WARRAM, JH ^{[1
]}

MARTIN, BC ^{[1
]}

KROLEWSKI, AS ^{[1
]}

SOELDNER, JS ^{[1
]}

KAHN, CR ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1990年 / 113卷 / 12期

关键词：

Blood glucose; Diabetes mellitus; non-insulin-dependent; Glucose tolerance test; Hyperinsulinism; Insulin;

D O I：

10.7326/0003-4819-113-12-909

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One to two decades before type II diabetes is diagnosed, reduced glucose clearance is already present. This reduced clearance is accompanied by compensatory hyperinsulinemia, not hypoinsulinemia, suggesting that the primary defect is in peripheral tissue response to insulin and glucose, not in the pancreatic beta cell.

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收藏

页码：909 / 915

页数：7

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