Tissue-engineered constructs for urethral regeneration

被引：4
作者：
Chen, Kuo-Liang [1 ,2 ]
Wu, Hsi-Chin [1 ,2 ]
Chang, Chao-Hsiang [1 ,2 ]
机构：
[1] China Med Univ Hosp, Dept Urol, Taichung 40402, Taiwan
[2] China Med Univ, Sch Med, Taichung 40402, Taiwan
来源：
UROLOGICAL SCIENCE | 2012年 / 23卷 / 02期
关键词：
reconstructive surgery; tissue engineering; urethroplasty;
D O I：
10.1016/j.urols.2012.04.003
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Those who have urethral injury, long-distance urethral stricture, hypospadias, or epispadias need tissue for urethral repair. Tissue engineering is one of the solutions for urethroplasty. Three components essential for tissue engineering are cells, scaffolds, and bioactive factors. Several animal studies of tissueengineered urethras have been conducted and progressed to human clinical trials by 1999. These studies have shown that the maximum distance for normal tissue regeneration in tubularized urethral replacement with unseeded matrices is 0.5 cm. Although autologous tissue-engineered tabularized urethras have been successful in clinical trials, this method could be an alternative treatment for urethral reconstruction. Copyright (C) 2012, Taiwan Urological Association. Published by Elsevier Taiwan LLC. Open access under CC BY-NC-ND license.
引用
收藏
页码：42 / 44
页数：3
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