THE FISSION YEAST PRP4+ GENE INVOLVED IN PREMESSENGER RNA SPLICING CODES FOR A PREDICTED SERINE/THREONINE KINASE AND IS ESSENTIAL FOR GROWTH

被引：43
作者：
ALAHARI, SK
SCHMIDT, H
KAUFER, NF
机构：
[1] DREXEL UNIV, DEPT BIOSCI & BIOTECHNOL, PHILADELPHIA, PA 19104 USA
[2] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG, BIOZENTRUM, INST GENET, D-38106 BRAUNSCHWEIG, GERMANY
来源：
NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 17期
关键词：
D O I：
10.1093/nar/21.17.4079
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Only four prp (pre-mRNA processing) genes of the fission yeast Schizosaccharomyces pombe have been reported. We exploited yeast genetics and identified and isolated the prp4 gene. Sequence analysis revealed that the splicing factor encoded by this gene contains the signature sequences that define the serine/threonine protein kinase family. This is the first kinase gene identified whose product is involved in pre-mRNA splicing. The prp4 gene contains one intron in the kinase domain. Gene replacement studies provided evidence that this gene is essential for growth and is located on chromosome III.
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页码：4079 / 4083
页数：5
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