INCREASE OF SEROTONIN IN PLASMA DURING ONSET OF HALOTHANE-INDUCED MALIGNANT HYPERTHERMIA IN PIGS

被引:18
作者
GERDES, C [1 ]
RICHTER, A [1 ]
ANNIES, R [1 ]
LOSCHER, W [1 ]
机构
[1] HANNOVER SCH VET MED,DEPT PHARMACOL TOXICOL & PHARM,BUNTEWEG 17,W-3000 HANNOVER 71,GERMANY
关键词
SKELETAL MUSCLES; 5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); (SWINE);
D O I
10.1016/0014-2999(92)90016-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The levels of serotonin (5-HT) were determined in platelet-free and platelet-rich plasma before and during the onset of halothane-induced malignant hyperthermia (MH) in genetically MH-susceptible pigs. During MH onset, the free (i.e. physiologically active) levels of 5-HT in plasma rose concomitantly with the increases in muscle tone, body temperature, venous pCO2 and plasma lactate. Since pharmacological stimulation of 5-HT2 receptors has recently been shown to trigger MH in susceptible pigs, the finding of increased 5-HT plasma levels during onset of halothane-induced MH may indicate that 5-HT is involved in the mechanisms by which volatile anesthetics trigger this myopathic syndrome.
引用
收藏
页码:91 / 94
页数:4
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