SYNTHESIS OF AMINO-ACID DERIVATIVES OF KOJIC ACID AND THEIR TYROSINASE INHIBITORY ACTIVITY

被引：36

作者：

KOBAYASHI, Y

KAYAHARA, H

TADASA, K

NAKAMURA, T

TANAKA, H

机构：

[1] GIFU UNIV, UNITED GRAD SCH AGR SCI, GIFU 50111, JAPAN

[2] SHINSHU UNIV, FAC AGR, DEPT BIOSCI & BIOTECHNOL, NAGANO 39945, JAPAN

[3] LAB NARIS COSMET CO LTD, FUKUSHIMA KU, OSAKA 553, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 09期

关键词：

D O I：

10.1271/bbb.59.1745

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six N-carbobenzozy amino acid derivatives of kojic acid were synthesized to improve the tyrosinase inhibitory activity of kojic acid, All derivatives showed stronger activities than kojic acid, Among them, the L-phenylalanine derivative was the strongest inhibitor and its IC50 value was about 1/80 that for kojic acid, The inhibition mechanism of these derivatives is considered to be a noncompetitive one similar to that of kojic acid.

引用

页码：1745 / 1746

页数：2

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