CHEMICAL SYNTHESIS OF RNA-FRAGMENT ANALOGS THAT HAVE PHOSPHOROTHIOATE LINKAGES OF IDENTICAL CONFIGURATION

被引：3

作者：

ALMER, H ^{[1
]}

STAWINSKI, J ^{[1
]}

STROMBERG, R ^{[1
]}

机构：

[1] UNIV STOCKHOLM,ARRHENIUS LAB,DEPT ORGAN CHEM,S-10691 STOCKHOLM,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 3-5期

关键词：

D O I：

10.1080/15257779508012494

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligouridine all-Rp-phosphorothioates were synthesized using the H-phosphonate approach followed by silfurisation with S-8 and treatment with nuclease P1. The degree of stereoselection in the couplings is reported for different 2'-O-silyl protecting groups. The influence of the heterocyclic base was also investigated.

引用

页码：879 / 881

页数：3

共 9 条

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