THE ANALGESIC EFFECT OF EPIBATIDINE AND ISOMERS

被引：49

作者：

LI, TC

QIAN, CG

ECKMAN, J

HUANG, DF

SHEN, TY

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22903

[2] CYTOMED INC,CAMBRIDGE,MA 02139

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80759-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The racemic form, d and l-enantiomers and the 7-N-methyl derivative of synthetic epibatidine are equally potent at 10 mug/kg in the tail-flick analgesic model without any enantioselectivity, whereas the endo-stereoisomer is not active at 1 mg/kg. The analgesic response is not antagonized by pretreatment with naloxone.

引用

收藏

页码：2759 / 2764

页数：6

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