POLYENE ANTIBIOTICS INHIBIT SUPEROXIDE-PRODUCING NADPH OXIDASE IN A POLYMORPHONUCLEAR CELL-FREE SYSTEM

被引：1
作者：
CAPUOZZO, E
CRIFO, C
SALERNO, C
机构：
[1] UNIV ROMA LA SAPIENZA,DEPT HUMAN BIOPATHOL,V REGINA ELENA 324 POLICLIN,I-00185 ROME,ITALY
[2] UNIV ROMA LA SAPIENZA,DEPT BIOCHEM SCI,I-00185 ROME,ITALY
[3] CNR,CTR MOLEC BIOL,ROME,ITALY
来源：
BIOCHEMICAL PHARMACOLOGY | 1993年 / 45卷 / 03期
关键词：
D O I：
10.1016/0006-2952(93)90153-N
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We studied the effect of polyene macrolide antibiotics on the NADPH-dependent superoxide production induced by arachidonic acid in a cell-free system consisting of the membrane and cytosolic fractions obtained from bovine polymorphonuclear leukocytes. Preincubation of the membrane fraction with polyenes before addition of the soluble components of the reaction mixture resulted in a dose-dependent inhibition of superoxide production.
引用
收藏
页码：766 / 768
页数：3
相关论文
共 10 条
[1]   HOW DO THE POLYENE MACROLIDE ANTIBIOTICS AFFECT THE CELLULAR MEMBRANE-PROPERTIES [J].
BOLARD, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 864 (3-4) :257-304
[2]   KINETICS OF BINDING OF LUCENSOMYCIN TO NATURAL AND ARTIFICIAL MEMBRANES [J].
CAPUOZZO, E ;
SALERNO, C ;
STROM, R ;
CRIFO, C .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1987, 167 (01) :59-64
[3]   INHIBITORS OF THE LEUKOCYTE SUPEROXIDE GENERATING OXIDASE - MECHANISMS OF ACTION AND METHODS FOR THEIR ELUCIDATION [J].
CROSS, AR .
FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (01) :71-93
[4]   CYTOSOLIC FACTORS IN BOVINE NEUTROPHIL OXIDASE ACTIVATION - PARTIAL-PURIFICATION AND DEMONSTRATION OF TRANSLOCATION TO A MEMBRANE-FRACTION [J].
DOUSSIERE, J ;
PILLOUD, MC ;
VIGNAIS, PV .
BIOCHEMISTRY, 1990, 29 (09) :2225-2232
[5]   EFFECTS OF POLYENE ANTIBIOTICS ON THE ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].
JULLIEN, S ;
CAPUOZZO, E ;
SALERNO, C ;
CRIFO, C .
BIOCHEMICAL PHARMACOLOGY, 1991, 41 (12) :2037-2040
[6]  
JULLIEN S, 1991, BIOCHEM INT, V24, P307
[7]   ACTIVATION OF THE O2--GENERATING OXIDASE IN PLASMA-MEMBRANE FROM BOVINE POLYMORPHONUCLEAR NEUTROPHILS BY ARACHIDONIC-ACID, A CYTOSOLIC FACTOR OF PROTEIN NATURE, AND NONHYDROLYZABLE ANALOGS OF GTP [J].
LIGETI, E ;
DOUSSIERE, J ;
VIGNAIS, PV .
BIOCHEMISTRY, 1988, 27 (01) :193-200
[8]   THE O-2(-)-FORMING NADPH OXIDASE OF THE PHAGOCYTES - NATURE, MECHANISMS OF ACTIVATION AND FUNCTION [J].
ROSSI, F .
BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 853 (01) :65-89
[9]  
SEIFERT R, 1991, REV PHYSL BIOCH PHAR, V117, P177
[10]   TEMPERATURE-DEPENDENT MODES FOR THE BINDING OF THE POLYENE ANTIBIOTIC AMPHOTERICIN-B TO HUMAN-ERYTHROCYTE MEMBRANES - A CIRCULAR-DICHROISM STUDY [J].
SZPONARSKI, W ;
BOLARD, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 897 (02) :229-237
1