O-VANILLIN ENHANCES CHROMOSOME-ABERRATIONS INDUCED BY ALKYLATING-AGENTS IN CULTURED CHINESE-HAMSTER CELLS

被引：8

作者：

MATSUMURA, H ^{[1
]}

WATANABE, K ^{[1
]}

OHTA, T ^{[1
]}

机构：

[1] INST ENVIRONM TOXICOL,SUZUKI CHO 2-772,KODAIRA,TOKYO 187,JAPAN

来源：

MUTATION RESEARCH | 1993年 / 298卷 / 03期

关键词：

O-VANILLIN; VANILLIN; MNNG; ALKYLATING AGENTS; ENHANCING EFFECT; (CHL CELLS);

D O I：

10.1016/0165-1218(93)90037-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The enhancing effects of o-vanillin (2-hydroxy-3-methoxybenzaldehyde) on structural chromosome aberrations induced by alkylating agents were studied in cultured Chinese hamster cells. o-Vanillin was not a clastogen by itself. When cells were treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the presence of 400 mug/ml of o-vanillin for 2 h, the frequency of aberrant cells with chromosome aberrations was increased 2.8-fold compared with cells treated with MNNG alone. The total number of breakage-type and exchange-type aberrations was increased 18.5- and 8.3-fold, respectively. The enhancing effects were also observed for chromosome aberrations induced by N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea. On the other hand, those induced by N-butyl-N-nitrosourea were only slightly enhanced. The frequency of chromosome aberrations induced by mitomycin C or bleomycin was not changed by o-vanillin treatment. It was considered that DNA repair of methylated damage may be inhibited by o-vanillin.

引用

页码：163 / 168

页数：6

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