STUDIES ON TOXICOLOGICAL MECHANISMS OF GAS-PHASE CIGARETTE-SMOKE AND PROTECTION EFFECTS OF GTP

被引：2
作者：
YANG, FJ
ZHAO, BL
XIN, WJ
机构：
[1] Institute of Biophysics, Acadetnia Sinica, Beijing
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 1992年 / 17卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1163/156856792X00047
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Gas-phase cigarette smoke (GPCS) was able to induce lipid peroxidation in lecithin liposomes, rat liver microsomes, and rat lung cells (RLC), and change the membrane fluidity of RLCs. Lipid free radicals were trapped in a GPCS-treated microsomal suspension by using 4-POBN as the spin trap. In addition, it was found that GPCS-peroxidized liposomes in appropriate degree of lipid peroxidation had the bility to increase the generation of superoxide anions in rat peritoneal neutrophils (RPN). Effects of green tea polyphenols (GTP) on the GPCS-induced damages were investigated. The results showed that GTP was capable of inhibiting the GPCS-induced damages.
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页码：39 / 57
页数：19
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