A CONVENIENT CHEMOENZYMATIC SYNTHESIS OF (R)-(CHLOROMETHYL)OXIRANE AND (S)-(CHLOROMETHYL)OXIRANE

被引：23

作者：

CHEN, CS

LIU, YC

MARSELLA, M

机构：

[1] Department of Pharmacognosy and Environmental Health Sciences, College of Pharmacy, University of Rhode Island, Kingston

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 09期

关键词：

D O I：

10.1039/p19900002559

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R)- and (S)-1-Chloro-3-tosyloxypropan-2-ol have been prepared by biocatalysed enantioselective esterification in hexane, and in turn could be readily converted into optically active (chloromethyl)oxirane in high yield.

引用

页码：2559 / 2561

页数：3

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