SYNTHESIS AND CHARACTERISATION OF CHALCONE BASED COPOLYESTERS AND THEIR ANTICANCER ACTIVITY

Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyesters were characterized by solubility and viscosity measurements. The structure of the copolyesters was established by FT-IR, H-1 NMR, C-13 NMR and MALDI. The monomer and copolyesters were studied for their anticancer activity using MCF-7 Cell Line and their cytotoxic effect were studied on VERO Cell Line by MTT assay. The IC50 values were calculated using the Software Graph Pad Prism Version 7 and ED50 plus v 1.0. The Selectivity index indicates that the chalcone HHEP and the two copolyesters are good anticancer agents and the chalcone MHEP is cytotoxic. The Selectivity index were found to be more than two, these copolyesters can be targeted individually or in combination with cancer drug in chemotherapy.