PROTON MAGNETIC-RESONANCE SPECTROSCOPY STUDIES IN LACTIC-ACIDOSIS AND MITOCHONDRIAL DISORDERS

被引：40
作者：
CROSS, JH
GADIAN, DG
CONNELLY, A
LEONARD, JV
机构：
[1] INST CHILD HLTH,GREAT ORMOND ST,LONDON WC1N 3JH,ENGLAND
[2] HOSP SICK CHILDREN,LONDON WC1N 3JH,ENGLAND
来源：
JOURNAL OF INHERITED METABOLIC DISEASE | 1993年 / 16卷 / 04期
关键词：
D O I：
10.1007/BF00711912
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Congenital lactic acidoses form a large group of disorders that are commonly associated with profound neurological dysfunction. Difficulties are frequently encountered in establishing a diagnosis, and the mechanisms underlying brain damage are poorly understood. We have performed proton magnetic resonance spectroscopy (H-1-MRS) on 24 patients under investigation for suspected metabolic disorder, and have compared the MRS observations of brain lactate with measurements of cerebrospinal fluid (CSF) lactate. We have shown good concordance between the two types of observation, confirming the value of the CSF measurements. Regional variations in brain lactate are detected in some cases, and these may help to elucidate the mechanisms underlying selective brain damage.
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页码：800 / 811
页数：12
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