COLOCALIZATION OF F-ACTIN AND TALIN DURING FC RECEPTOR MEDIATED PHAGOCYTOSIS IN MOUSE MACROPHAGES

被引：99

作者：

GREENBERG, S

BURRIDGE, K

SILVERSTEIN, SC

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,ROVER LAB CELLULAR PHYSIOL,NEW YORK,NY 10032

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,NEW YORK,NY 10032

[3] COLUMBIA UNIV COLL PHYS & SURG,DEPT PHYSIOL & CELLULAR BIOPHYS,NEW YORK,NY 10032

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 06期

关键词：

D O I：

10.1084/jem.172.6.1853

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have studied the distribution oftalin inJ774 cells and mouse peritoneal macrophages undergoing Fc receptor-mediated phagocytosis. At early stages ofphagocytosis, talin accumulates in the cells' cortical cytoplasm adjacent to the forming phagosome and extends into pseudopods that are encircling the particle. Talin colocalizes with F-actin at these sites. After particle ingestion is completed, F-actin and talin are no longer concentrated adjacent to phagosomes. Thus, talin and F-actin undergo dynamic and coordinate changes in their cytoplasmic location during Fc receptor-mediated phagocytosis. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：1853 / 1856

页数：4

共 23 条

[1] INHIBITION OF PHAGOCYTOSIS OF COMPLEMENT-C3-COATED OR IMMUNOGLOBULIN-G-COATED PARTICLES AND OF C3BI BINDING BY MONOCLONAL-ANTIBODIES TO A MONOCYTE-GRANULOCYTE MEMBRANE GLYCOPROTEIN (MOL) [J].