Nasal Reflexes: Reduced Sensitivity to CO2 Irritation in Cigarette Smokers

被引:42
作者
Dunn, Jan D.
Enrique Cometto-Muniz, J. [2 ]
Cain, William S. [1 ]
机构
[1] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06519 USA
[2] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina
关键词
cigarettes; trigeminal nerve; carbon dioxide;
D O I
10.1002/jat.2550020312
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Carbon dioxide inhaled through the nose in concentrations above 10% evokes nasal irritation. As concentration is increased, a non- systemic, reflexive interruption of inhalation eventually occurs in most persons. This study revealed that smokers have a considerably higher threshold for the reflex. The elevation of threshold occurred to a comparable degree in both male and female smokers, although females generally had a lower threshold than males. It therefore appears that smokers have less sensitivity to nasal irritants. This marks the fist instance of a substantial chemosensory difference between smokers and nonsmokers.
引用
收藏
页码:176 / 178
页数:3
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