REGULATION OF ADIPOCYTE GENE-EXPRESSION AND DIFFERENTIATION BY PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-GAMMA

被引：386
作者：
TONTONOZ, P
HU, E
SPIEGELMAN, BM
机构：
[1] DANA FARBER CANC INST,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,BOSTON,MA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期
关键词：
D O I：
10.1016/0959-437X(95)80025-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Peroxisome proliferator activated receptor (PPAR) gamma is an orphan member of the nuclear hormone receptor superfamily and is expressed at high levels specifically in adipose tissue. Recent data suggest that this factor is a central regulator of adipocyte gene expression and differentiation. Fibroblastic cell lines that express PPAR gamma ectopically can be induced to differentiate into fat cells by a variety of lipids and lipid-like activators of PPARs, suggesting that this protein may function to link adipogenesis with systemic lipid metabolism.
引用
收藏
页码：571 / 576
页数：6
相关论文
共 51 条
[1]   CELLULAR AND MOLECULAR ASPECTS OF ADIPOSE-TISSUE DEVELOPMENT [J].
AILHAUD, G ;
GRIMALDI, P ;
NEGREL, R .
ANNUAL REVIEW OF NUTRITION, 1992, 12 :207-233
[2]   CLONING OF A PROTEIN THAT MEDIATES TRANSCRIPTIONAL EFFECTS OF FATTY-ACIDS IN PREADIPOCYTES - HOMOLOGY TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS [J].
AMRI, EZ ;
BONINO, F ;
AILHAUD, G ;
ABUMRAD, NA ;
GRIMALDI, PA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (05) :2367-2371
[3]   ADIPOCYTE CONVERSION OF CULTURED 3T3-L1 PREADIPOCYTES BY BEZAFIBRATE [J].
BRANDES, R ;
HERTZ, R ;
ARAD, R ;
NAISHTAT, S ;
WEIL, S ;
BARTANA, J .
LIFE SCIENCES, 1987, 40 (10) :935-941
[4]   REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS [J].
CAO, ZD ;
UMEK, RM ;
MCKNIGHT, SL .
GENES & DEVELOPMENT, 1991, 5 (09) :1538-1552
[5]   PEROXISOME PROLIFERATOR AND RETINOID SIGNALING PATHWAYS COREGULATE PREADIPOCYTE PHENOTYPE AND SURVIVAL [J].
CHAWLA, A ;
LAZAR, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) :1786-1790
[6]   PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-GAMMA - ADIPOSE-PREDOMINANT EXPRESSION AND INDUCTION EARLY IN ADIPOCYTE DIFFERENTIATION [J].
CHAWLA, A ;
SCHWARZ, EJ ;
DIMACULANGAN, DD ;
LAZAR, MA .
ENDOCRINOLOGY, 1994, 135 (02) :798-800
[7]   IDENTIFICATION OF 2 MESSENGER PPAR RELATED RECEPTORS AND EVIDENCE FOR THE EXISTENCE OF 5 SUBFAMILY MEMBERS [J].
CHEN, F ;
LAW, SW ;
OMALLEY, BW .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (02) :671-677
[8]   DIFFERENTIATION-INDUCED GENE-EXPRESSION IN 3T3-L1 PREADIPOCYTES - CCAAT ENHANCER BINDING-PROTEIN INTERACTS WITH AND ACTIVATES THE PROMOTERS OF 2 ADIPOCYTE-SPECIFIC GENES [J].
CHRISTY, RJ ;
YANG, VW ;
NTAMBI, JM ;
GEIMAN, DE ;
LANDSCHULZ, WH ;
FRIEDMAN, AD ;
NAKABEPPU, Y ;
KELLY, TJ ;
LANE, MD .
GENES & DEVELOPMENT, 1989, 3 (09) :1323-1335
[9]   CCAAT ENHANCER BINDING-PROTEIN GENE PROMOTER - BINDING OF NUCLEAR FACTORS DURING DIFFERENTIATION OF 3T3-L1 PREADIPOCYTES [J].
CHRISTY, RJ ;
KAESTNER, KH ;
GEIMAN, DE ;
LANE, MD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2593-2597
[10]   DEVELOPMENTALLY REGULATED MESSENGER-RNAS IN 3T3-ADIPOCYTES - ANALYSIS OF TRANSCRIPTIONAL CONTROL [J].
COOK, KS ;
HUNT, CR ;
SPIEGELMAN, BM .
JOURNAL OF CELL BIOLOGY, 1985, 100 (02) :514-520
123456