AGGRAVATION OF ISCHEMIC NEURONAL DAMAGE IN THE RAT HIPPOCAMPUS BY IMPAIRMENT OF HISTAMINERGIC NEUROTRANSMISSION

被引：30

作者：

ADACHI, N

OISHI, R

ITANO, Y

YAMADA, T

HIRAKAWA, M

SAEKI, K

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT PHARMACOL,2-5-1 SHIKATA CHO,OKAYAMA 700,JAPAN

[2] OKAYAMA UNIV,SCH MED,DEPT ANESTHESIOL & RESUSCITOL,OKAYAMA 700,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 602卷 / 01期

关键词：

HISTAMINE; ALPHA-FLUOROMETHYLHISTIDINE; MEPYRAMINE; CEREBRAL ISCHEMIA; 4-VESSEL OCCLUSION; DELAYED NEURONAL DEATH;

D O I：

10.1016/0006-8993(93)90259-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Delayed damage to hippocampal CA1 pyramidal cells was observed in rats subjected to cerebral ischemia caused by 10 min of 4-vessel occlusion. Animals pretreated with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, showed significantly more necrotic cells than did control animals. Mepyramine (H-1-antagonist) and (R)alpha-methylhistamine (H-3-agonist), but not zolantidine (H-2-antagonist), significantly aggravated the delayed neuronal death. These results suggest that histaminergic neurons have a protective role, probably via H-1-receptors, in the development of delayed neuronal death caused by cerebral ischemia.

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收藏

页码：165 / 168

页数：4

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