LOCALIZATION OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE IN THE HUMAN CORPUS-LUTEUM

被引：8
作者：
KAUMA, SW
CURRY, TE
POWELL, DE
CLARK, MR
机构：
[1] Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC
[2] Department of Obstetrics and Gynecology, University of Kentucky, Lexington, KY
[3] Department of Pathology, University of Kentucky, Lexington, KY
来源：
HUMAN REPRODUCTION | 1990年 / 5卷 / 07期
关键词：
Corpus luteum; Cyclooxygenase; Immunohistochemistry; Prostaglandin endoperoxide synthase;
D O I：
10.1093/oxfordjournals.humrep.a137186
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Prostaglandins have been implicated in both maintenance and luteolysis of the primate corpus luteum. Central to the production of prostaglandins is the enzyme prostaglandin endoperoxide synthase (PGHS). In the present study, we identified the cell types which contain PGHS in 44 human corpora lutea, using immunoperoxidase staining techniques. Intense granular staining was present in the cytoplasm of granulosa lutein cells of tissues obtained from the mid-luteal phase. Theca lutein cells demonstrated a diffuse cytoplasmic staining which was less intense than that observed in granulosa lutein cells. Staining appeared less intense in tisues from the early or late phase. Ovarian stromal cells demonstrated little or no PGHS immunoreactivity. PGHS staining in the corpus luteum of pregnancy was similar in intensity and cell distribution to that of mid-luted corpus luteum. In summary, human corpus luteum contains immunoreactive PGHS which localized mainly to welldifferentiated granulosa lutein cells. © 1990 Oxford University Press.
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页码：800 / 804
页数：5
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