ACID GASTRIC-SECRETION INDUCED WITH GASTRIN AND HISTAMINE IN PREGNANT RATS

被引：2

作者：

BOLARINWA, Y ^{[1
]}

AMURE, BO ^{[1
]}

机构：

[1] UNIV IBADAN, DEPT PHYSIOL, IBADAN, NIGERIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1976年 / 28卷 / 11期

关键词：

D O I：

10.1111/j.2042-7158.1976.tb04075.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Histamine dihydrochloride and synthetic human gastrin were administered to pregnant and non-pregnant rats. The acid secretory responses were greater to gastrin than to histamine in all animals (P < 0.02). The pregnant rats appeared to respond more to gastrin than did the non-pregnant rats. Mid-pregnant > non-pregnant (P > 0.02), late-pregnant > non-pregnant (P > 0.001). The varying responses of the animals at different stages of pregnancy are consistent with the increase in the population of the parietal cells at this period or might also be due to the influence of estrogen on acid secretion. This data may have some application to the observed amelioration of ulcer symptoms in women during pregnancy.

引用

页码：851 / 852

页数：2

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