NANOPATTERNED INTERFACES FOR CONTROLLING CELL BEHAVIOR

被引:15
作者
Chung, Kevin [1 ]
Dequach, Jessica A. [1 ]
Christman, Karen L. [1 ]
机构
[1] Univ Calif San Diego, Dept Bioengn, 9500 Gilman Dr, La Jolla, CA 92093 USA
关键词
Nanopatterns; nanotopography; cell adhesion; differentiation; surface modification;
D O I
10.1142/S1793984410000055
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Many studies have demonstrated that microscale changes to surface chemistry and topography affect cell adhesion, proliferation, differentiation, and gene expression. More recently, studies have begun to examine cell behavior interactions with structures on the nanoscale since in vivo, cells recognize and adhere to cell adhesion receptors that are spatially organized on this scale. These studies have been enabled through various fabrication methods, many of which were initially developed for the semiconductor industry. This review explores cell responses to a variety of controlled topographical and biochemical cues using an assortment of nanoscale fabrication methods in order to elucidate which pattern dimensions are beneficial for controlling cell adhesion and differentiation.
引用
收藏
页码:63 / 77
页数:15
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