IN-VITRO ACTIVITY OF RP-59500 (QUINUPRISTIN DALFOPRISTIN) AGAINST ANTIBIOTIC-RESISTANT STRAINS OF STREPTOCOCCUS-PNEUMONIAE AND ENTEROCOCCI

被引：40

作者：

JOHNSON, CC ^{[1
]}

SLAVOSKI, L ^{[1
]}

SCHWARTZ, M ^{[1
]}

MAY, P ^{[1
]}

PITSAKIS, PG ^{[1
]}

SHUR, AL ^{[1
]}

LEVISON, ME ^{[1
]}

机构：

[1] DEPT VET AFFAIRS,PHILADELPHIA,PA 19104

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1995年 / 21卷 / 03期

关键词：

D O I：

10.1016/0732-8893(95)00068-L

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resistant Enterococcus faecium, but showed poor activity against E. faecalis. In time-kill studies the drug was rapidly bactericidal against S. pneumoniae but failed to kill most enterococci, even in the presence of gentamicin or human serum.

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页码：169 / 173

页数：5

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