IDENTIFICATION OF A CDNA-ENCODING A DROSOPHILA CALCIUM/CALMODULIN REGULATED PROTEIN PHOSPHATASE, WHICH HAS ITS MOST ABUNDANT EXPRESSION IN THE EARLY EMBRYO

被引：20

作者：

BROWN, L ^{[1
]}

CHEN, MX ^{[1
]}

COHEN, PTW ^{[1
]}

机构：

[1] UNIV DUNDEE, MED RES COUNCIL, DEPT BIOCHEM, PROT PHOSPHORYLAT UNIT, DUNDEE DD1 4HN, SCOTLAND

来源：

FEBS LETTERS | 1994年 / 339卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

PROTEIN PHOSPHATASE 2B; CALCINEURIN; CDNA SEQUENCE; CALCIUM; CALMODULIN; DROSOPHILA MELANOGASTER;

D O I：

10.1016/0014-5793(94)80398-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 3.3 kb cDNA encoding the complete amino acid sequence of a calcium/calmodulin regulated protein phosphatase has been isolated from a Drosophila eye disc cDNA library. The predicted protein of 560 amino acids (molecular mass 62 kDa) is 73-78% identical to human PP2B isoforms. The cDNA hybridised to the X-chromosome al cytological position 14D1-4. Two transcripts of 3.5 kb and 3.0 kb were expressed during embryonic development, their levels being highest in the early embryo. The larger transcript was also clearly present in adult females. This pattern of expression indicates a role for calcium/calmodulin regulated protein phosphatase in embryonic development.

引用

页码：124 / 128

页数：5

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