ANTISENSE C-MYB OLIGONUCLEOTIDES INHIBIT INTIMAL ARTERIAL SMOOTH-MUSCLE CELL ACCUMULATION INVIVO

被引：679

作者：

SIMONS, M

EDELMAN, ER

DEKEYSER, JL

LANGER, R

ROSENBERG, RD

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[2] MIT,DIV HLTH SCI TECHNOL,CAMBRIDGE,MA 02139

[3] MIT,DEPT CHEM ENGN,CAMBRIDGE,MA 02139

[4] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DEPT MED,BOSTON,MA 02215

来源：

NATURE | 1992年 / 359卷 / 6390期

关键词：

D O I：

10.1038/359067a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SYNTHETIC antisense oligonucleotides have been used to dissect gene function in vitro. Technical difficulties prevented the use of this approach for investigating the effect of gene products in vivo. Here we report the use of local delivery of antisense c-myb oligonucleotide to suppress intimal accumulation of rat carotid arterial smooth muscle cells. Our results suggest that antisense oligonucleotides can be used to define the in vivo biological role of specific macromolecules in the blood vessel wall and could potentially serve as a new class of therapeutic agents for cardiovascular disorders.

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页码：67 / 70

页数：4

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