RIBOZYME INHIBITORS - DEOXYGUANOSINE AND DIDEOXYGUANOSINE ARE COMPETITIVE INHIBITORS OF SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL RIBONUCLEIC-ACID PRECURSOR

被引：100
作者：
BASS, BL [1 ]
CECH, TR [1 ]
机构：
[1] UNIV COLORADO,DEPT CHEM & BIOCHEM,BOULDER,CO 80309
来源：
BIOCHEMISTRY | 1986年 / 25卷 / 16期
关键词：
D O I：
10.1021/bi00364a001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：4473 / 4477
页数：5
相关论文
共 27 条
[1]   ASPECTS OF BIOCHEMICAL CATALYSIS [J].
ALTMAN, S .
CELL, 1984, 36 (02) :237-239
[2]   SPECIFIC INTERACTION BETWEEN THE SELF-SPLICING RNA OF TETRAHYMENA AND ITS GUANOSINE SUBSTRATE - IMPLICATIONS FOR BIOLOGICAL CATALYSIS BY RNA [J].
BASS, BL ;
CECH, TR .
NATURE, 1984, 308 (5962) :820-826
[3]   ROLE OF CONSERVED SEQUENCE ELEMENT-9L AND ELEMENT-2 IN SELF-SPLICING OF THE TETRAHYMENA RIBOSOMAL-RNA PRECURSOR [J].
BURKE, JM ;
IRVINE, KD ;
KANEKO, KJ ;
KERKER, BJ ;
OETTGEN, AB ;
TIERNEY, WM ;
WILLIAMSON, CL ;
ZAUG, AJ ;
CECH, TR .
CELL, 1986, 45 (02) :167-176
[4]  
BUTLER ET, 1982, J BIOL CHEM, V257, P5772
[5]   BIOLOGICAL CATALYSIS BY RNA [J].
CECH, TR ;
BASS, BL .
ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :599-629
[6]   INVITRO SPLICING OF THE RIBOSOMAL-RNA PRECURSOR OF TETRAHYMENA - INVOLVEMENT OF A GUANOSINE NUCLEOTIDE IN THE EXCISION OF THE INTERVENING SEQUENCE [J].
CECH, TR ;
ZAUG, AJ ;
GRABOWSKI, PJ .
CELL, 1981, 27 (03) :487-496
[7]   SECONDARY STRUCTURE OF THE TETRAHYMENA RIBOSOMAL-RNA INTERVENING SEQUENCE - STRUCTURAL HOMOLOGY WITH FUNGAL MITOCHONDRIAL INTERVENING SEQUENCES [J].
CECH, TR ;
TANNER, NK ;
TINOCO, I ;
WEIR, BR ;
ZUKER, M ;
PERLMAN, PS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (13) :3903-3907
[8]   CHARACTERIZATION OF THE INTRON IN THE PHAGE-T4 THYMIDYLATE SYNTHASE GENE AND EVIDENCE FOR ITS SELF-EXCISION FROM THE PRIMARY TRANSCRIPT [J].
CHU, FK ;
MALEY, GF ;
WEST, DK ;
BELFORT, M ;
MALEY, F .
CELL, 1986, 45 (02) :157-166
[9]  
DIXON M, 1979, ENZYMES, P346
[10]   HYDROGEN-BONDING AND BIOLOGICAL SPECIFICITY ANALYZED BY PROTEIN ENGINEERING [J].
FERSHT, AR ;
SHI, JP ;
KNILLJONES, J ;
LOWE, DM ;
WILKINSON, AJ ;
BLOW, DM ;
BRICK, P ;
CARTER, P ;
WAYE, MMY ;
WINTER, G .
NATURE, 1985, 314 (6008) :235-238
123