NITRIC-OXIDE DESTROYS ZINC-SULFUR CLUSTERS INDUCING ZINC RELEASE FROM METALLOTHIONEIN AND INHIBITION OF THE ZINC FINGER-TYPE YEAST TRANSCRIPTION ACTIVATOR LAC9

被引：244
作者：
KRONCKE, KD
FEHSEL, K
SCHMIDT, T
ZENKE, FT
DASTING, I
WESENER, JR
BETTERMANN, H
BREUNIG, KD
KOLBBACHOFEN, V
机构：
[1] UNIV DUSSELDORF,BIOMED RES CTR,INST MICROBIOL,DEPT MED,D-40001 DUSSELDORF,GERMANY
[2] UNIV DUSSELDORF,INST PHYS CHEM & ELECTROCHEM 1,D-40001 DUSSELDORF,GERMANY
[3] BAYER AG,CENT RES,D-51368 LEVERKUSEN,GERMANY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.1564
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nitric oxide, generated from S-nitrosocysteine or applied as gas mediates metal ion release from the Zn2+/Cd2+-complexing protein metallothionein via oxidation of SH-groups. Time-dependent S-nitrosylation and subsequent disulfide formation of metallothionein are demonstrated. Furthermore, nitric oxide inhibits DNA binding activity of the yeast transcription factor LAC9 containing a zinc finger like DNA binding domain. These results show that nitric oxide interacts with and destroys zinc-sulfur clusters in proteins. (C) 1994 Academic Press, Inc.
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页码：1105 / 1110
页数：6
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