THE MOLECULAR EPIDEMIOLOGY OF GROWTH SIGNAL-TRANSDUCTION PROTEINS

被引：14
作者：
BRANDTRAUF, PW
DEVIVO, I
MARION, MJ
HEMMINKI, K
机构：
[1] UNITE RECH HEPATITES SIDA & RETROVIRUS HUMAINS,LYON,FRANCE
[2] KAROLINSKA INST,CTR NUTR & TOXICOL,HUDDINGE,SWEDEN
来源：
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 1995年 / 37卷 / 01期
关键词：
D O I：
10.1097/00043764-199501000-00011
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Cellular proteins involved in growth signal transduction pathways represent potential molecular epidemiologic biomarkers for various disease processes of toxicologic interest, particularly cancer. In many instances, the proteins gain access to the extracellular environment and thus can be detected in easily accessible biological fluids such as serum or plasma. This paper reviews the experience with selected examples of such proteins, including growth factors, growth factor receptors, G proteins, and nuclear DNA-binding proteins, as serum or plasma biomarkers of disease.
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页码：77 / 83
页数：7
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