HETEROTYPIC LYMPHOPROLIFERATIVE RESPONSE IN PIGS VACCINATED WITH FOOT-AND-MOUTH-DISEASE VIRUS - INVOLVEMENT OF ISOLATED CAPSID PROTEINS

被引：36

作者：

SAIZ, JC ^{[1
]}

RODRIGUEZ, A ^{[1
]}

GONZALEZ, M ^{[1
]}

ALONSO, F ^{[1
]}

SOBRINO, F ^{[1
]}

机构：

[1] INIA,SANIDAD ANIM,EMBAJADORES 68,E-28012 MADRID,SPAIN

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-10-2601

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The in vitro viral lymphoproliferative response of pigs vaccinated against foot-and-mouth disease virus (FMDV) has been characterized. Peripheral blood mononuclear cells from immunized animals up to 1 year post-immunization (p.i.) showed a time-dependent FMDV-specific response, as assayed by virus-specific cellular blastogenesis. The optimum viral concentration decreased with time (around 20 weeks p.i.), and the response was faster and weaker. Lymphoproliferation appeared to be mainly due to CD4+ T cells. The response was heterotypic, being induced by all FMDV serotypes tested (C, A and O) after only two vaccinations with FMDV of serotype C (C-S8). Each individual structural protein assessed (VP1, VP2 and VP3) induced proliferation, with VP3 and VPI being more effective stimulators. In vitro serum neutralization activity and FMDV-specific IgG production were found to be active even at 1 year p.i.

引用

页码：2601 / 2607

页数：7

共 42 条

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