Changes in Erythrocyte Membrane in Type-2 Diabetes Mellitus with and without Dyslipidemia

被引：21

作者：

Kumar, Robby ^{[1
]}

Kumar, Amar Nagesh ^{[1
]}

Ahmed, Sakil ^{[2
]}

机构：

[1] SSR Med Coll, Dept Biochem, Mauritius, India

[2] Sagohra Coll, Biharsarif, India

来源：

JOURNAL OF DIABETES & METABOLISM | 2011年 / 2卷 / 06期

关键词：

ATPase; Diabetes mellitus; Dyslipidemia; Erythrocyte; Membrane;

D O I：

10.4172/2155-6156.1000141

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: In Diabetes mellitus there is decreased number of pump units on the erythrocyte membrane, altered lipid - protein interaction, depleted membrane anionic charge and enzyme glycation and peroxidation which account for many abnormal complications. Method: Diabetes subjects with and without dyslipidemia were selected along with healthy control then we correlate the changes in serum and erythrocyte membrane. Result: The lipid composition of membrane is significantly increased with cholesterol: phospholipid ratio and Na+ K(+)ATPase of membrane was decreased when compared to control. Conclusion: Lipid composition disturbances along with increased hyperglycemia which causes glycation of enzymes and oxidative stress causes the decrease in activity of Na+ K+- ATPase and other changes in erythrocyte membrane.

引用

页数：2

共 22 条

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Barcelo A, 2001, Rev Panam Salud Publica, V10, P300, DOI 10.1590/S1020-49892001001100002

[2] PREPARATION AND CHEMICAL CHARACTERISTICS OF HEMOGLOBIN-FREE GHOSTS OF HUMAN ERYTHROCYTES [J].