Lipid metabolism correction by antisense technology

被引：1

作者：

Afanasieva, O. I. ^{[1
]}

Pokrovsky, S. N. ^{[1
]}

机构：

[1] Russian Cardiol Res & Prod Complex, Tretya Cherepkovskaya Ul 15, Moscow 121552, Russia

来源：

RATIONAL PHARMACOTHERAPY IN CARDIOLOGY | 2013年 / 9卷 / 05期

关键词：

antisense therapy; antisense oligonucleotides; lipid metabolism disturbances; cardiovascular disease;

D O I：

10.20996/1819-6446-2013-9-5-532-541

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications. Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described.

引用

页码：532 / 541

页数：10

共 60 条

[1] RNAi therapeutics: Principles, prospects and challenges [J].

Aagaard, Lars ;

Rossi, John J. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (2-3) :75-86

[2]

Afanasieva OI, 2010, RATION PHARMACOTHER, V6, P474

[3] The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases [J].

不详 .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2007, 22 (12) :839-869

[4] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[5] Functional validation of new pathways in lipoprotein metabolism identified by human genetics [J].

Bauer, Robert C. ;

Stylianou, Ioannis M. ;

Rader, Daniel J. .

CURRENT OPINION IN LIPIDOLOGY, 2011, 22 (02) :123-128

[6] RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform [J].

Bennett, C. Frank ;

Swayze, Eric E. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2010, 50 :259-293

[7] A Primer for Morpholino Use in Zebrafish [J].

Bill, Brent R. ;

Petzold, Andrew M. ;

Clark, Karl J. ;

Schimmenti, Lisa A. ;

Ekker, Stephen C. .

ZEBRAFISH, 2009, 6 (01) :69-77

[8] 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets [J].

Birmingham, A ;

Anderson, EM ;

Reynolds, A ;

Ilsley-Tyree, D ;

Leake, D ;

Fedorov, Y ;

Baskerville, S ;

Maksimova, E ;

Robinson, K ;

Karpilow, J ;

Marshall, WS ;

Khvorova, A .

NATURE METHODS, 2006, 3 (03) :199-204

[9] Exploiting microRNAs for cell engineering and therapy [J].

Bratkovic, Tomaz ;

Glavan, Gordana ;

Strukelj, Borut ;

Zivin, Marko ;

Rogelj, Boris .

BIOTECHNOLOGY ADVANCES, 2012, 30 (03) :753-765

[10] Pharmacological strategies for lowering LDL cholesterol: statins and beyond [J].

Brautbar, Ariel ;

Ballantyne, Christie M. .

NATURE REVIEWS CARDIOLOGY, 2011, 8 (05) :253-265

← 1 2 3 4 5 6 →