EXAMINATION OF IMMUNE PARAMETERS AND HOST-RESISTANCE MECHANISMS IN B6C3F1 MICE FOLLOWING ADULT EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN

被引：79
作者：
HOUSE, RV
LAUER, LD
MURRAY, MJ
THOMAS, PT
EHRLICH, JP
BURLESON, GR
DEAN, JH
机构：
[1] CHEM IND INST TOXICOL,DEPT CELLULAR & MOLEC TOXICOL,IMMUNOTOXICOL LAB,RES TRIANGLE PK,NC 27709
[2] US EPA,HLTH EFFECTS RES LAB,RES TRIANGLE PK,NC 27711
来源：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1990年 / 31卷 / 03期
关键词：
D O I：
10.1080/15287399009531449
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Adult female B6C3F1 mice were given a single ip dose of 0, 0.1, 1.0, or 10.0 μg/kg 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and examined for immune function and host resistance 7-10 d later. Exposure to TCDD resulted in a significant dose-related decrease in induction of both IgM and IgC antibody-forming cells. This suppression was noted for both T-dependent and T-independent antigens. TCDD at a dosage of 10 μg/kg was shown to suppress production of antibody to viral hemagglutinin. © 1975 Taylor & Francis Group, LLC.
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页码：203 / 215
页数：13
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