Midlife Healthy-Diet Index and Late-Life Dementia and Alzheimer's Disease

被引：40

作者：

Eskelinen, Marjo H. ^{[11
,1
]}

Ngandu, Tiia ^{[1
,2
]}

Tuomilehto, Jaakko ^{[2
,3
,4
]}

Soininen, Hilkka ^{[1
,5
]}

Kivipelto, Miia ^{[1
,6
]}

机构：

[1] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[2] Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland

[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[4] South Ostrobothnia Cent Hosp, Seinajoki, Finland

[5] Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland

[6] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | 2011年 / 1卷 / 01期

基金：

芬兰科学院;

关键词：

Alzheimer's disease; Cohort studies; Dementia; Diet; Population-based studies; Risk factors;

D O I：

10.1159/000327518

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD). Methods: Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components. Results: Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders. Conclusions: Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：103 / 112

页数：10

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