ANERGIC T-CELLS AS SUPPRESSOR CELLS IN-VITRO

被引：348

作者：

LOMBARDI, G ^{[1
]}

SIDHU, S ^{[1
]}

BATCHELOR, R ^{[1
]}

LECHLER, R ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT IMMUNOL,LONDON W12 0NN,ENGLAND

来源：

SCIENCE | 1994年 / 264卷 / 5165期

关键词：

D O I：

10.1126/science.8202711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibition of antigen-specific and allospecific T cell proliferation. In order for the inhibition to occur, the anergic T cells had to be specific for the same antigen-presenting cells (APCs) as the T cells that were suppressed. The mechanism of this suppression appears to be competition for the APC surface and for locally produced interleukin-2.

引用

页码：1587 / 1589

页数：3

共 30 条

[1] MULTIPLE LEVELS OF PERIPHERAL TOLERANCE [J].

ARNOLD, B ;

SCHONRICH, G ;

HAMMERLING, GJ .

IMMUNOLOGY TODAY, 1993, 14 (01) :12-14

[2] SUPPRESSOR CELLS AND THEIR ROLE IN THE SURVIVAL OF IMMUNOLOGICALLY ENHANCED RAT-KIDNEY ALLOGRAFTS [J].

BATCHELOR, JR ;

PHILLIPS, BE ;

GRENNAN, D .

TRANSPLANTATION, 1984, 37 (01) :43-46

[3] ANTIGEN ANALOG MAJOR HISTOCOMPATIBILITY COMPLEXES ACT AS ANTAGONISTS OF THE T-CELL RECEPTOR [J].

DEMAGISTRIS, MT ;

ALEXANDER, J ;

COGGESHALL, M ;

ALTMAN, A ;

GAETA, FCA ;

GREY, HM ;

SETTE, A .

CELL, 1992, 68 (04) :625-634

[4]

DIMUTHU R, 1991, J IMMUNOL, V147, P3261

[5]

DING L, 1993, J IMMUNOL, V151, P1224

[6] TRANSFORMING GROWTH-FACTOR-BETA IS A POTENT INHIBITOR OF INTERLEUKIN-1 (IL-1) RECEPTOR EXPRESSION - PROPOSED MECHANISM OF INHIBITION OF IL-1 ACTION [J].

DUBOIS, CM ;

RUSCETTI, FW ;

PALASZYNSKI, EW ;

FALK, LA ;

OPPENHEIM, JJ ;

KELLER, JR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (03) :737-744

[7] ALLELE-SPECIFIC MOTIFS REVEALED BY SEQUENCING OF SELF-PEPTIDES ELUTED FROM MHC MOLECULES [J].

FALK, K ;

ROTZSCHKE, O ;

STEVANOVIC, S ;

JUNG, G ;

RAMMENSEE, HG .

NATURE, 1991, 351 (6324) :290-296

[8] 2 TYPES OF MOUSE T-HELPER CELL .4. TH2 CLONES SECRETE A FACTOR THAT INHIBITS CYTOKINE PRODUCTION BY TH1 CLONES [J].

FIORENTINO, DF ;

BOND, MW ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2081-2095

[9]

GO C, 1993, J IMMUNOL, V150, P367

[10] ALLOREACTIVE T-CELLS DISCRIMINATE AMONG A DIVERSE SET OF ENDOGENOUS PEPTIDES [J].

HEATH, WR ;

KANE, KP ;

MESCHER, MF ;

SHERMAN, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5101-5105

← 1 2 3 →