POSITIVE SELECTION OF T-CELLS

被引：74

作者：

FOWLKES, BJ

SCHWEIGHOFFER, E

机构：

[1] Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Building 4

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80003-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past year, significant technical developments have provided the opportunity to investigate the more mechanistic features of positive selection. Major progress has been made in determining the structure and function of the early pre-T cell receptor, in defining cell types that mediate positive selection, and in analyzing the contribution of MHC and co-receptors to CD4/CD8 lineage commitment. The most revealing studies have been those addressing the role of peptides in thymic selection.

引用

页码：188 / 195

页数：8

共 54 条

[21] A ROLE FOR THE CYTOPLASMIC TAIL OF THE BETA-CHAIN OF CD8 IN THYMIC SELECTION [J].

ITANO, A ;

CADO, D ;

CHAN, FKM ;

ROBEY, E .

IMMUNITY, 1994, 1 (04) :287-290

[22] CD3 COMPONENTS AT THE SURFACE OF PRO-T CELLS CAN MEDIATE PRE-T CELL-DEVELOPMENT IN-VIVO [J].

JACOBS, H ;

VANDEPUTTE, D ;

TOLKAMP, L ;

DEVRIES, E ;

BORST, J ;

BERNS, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (04) :934-939

[23] SPECIFICITY AND FLEXIBILITY IN THYMIC SELECTION [J].

JAMESON, SC ;

HOGQUIST, KA ;

BEVAN, MJ .

NATURE, 1994, 369 (6483) :750-752

[24] THYMIC SELECTION - 2 PATHWAYS TO LIFE AND 2 TO DEATH [J].

JANEWAY, CA .

IMMUNITY, 1994, 1 (01) :3-6

[25] POSITIVE SELECTION BY PURIFIED MHC CLASS II(+) THYMIC EPITHELIAL-CELLS IN-VITRO - COSTIMULATORY SIGNALS MEDIATED BY B7 ARE NOT INVOLVED [J].

JENKINSON, EJ ;

ANDERSON, G ;

MOORE, NC ;

SMITH, CA ;

OWEN, JJT .

DEVELOPMENTAL IMMUNOLOGY, 1994, 3 (04) :265-271

[26] THYMIC SELECTION OF CD8+ SINGLE POSITIVE CELLS WITH A CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED RECEPTOR [J].

KIRBERG, J ;

BARON, A ;

JAKOB, S ;

ROLINK, A ;

KARJALAINEN, K ;

VONBOEHMER, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) :25-34

[27] AN INVARIANT T-CELL RECEPTOR-ALPHA CHAIN IS USED BY A UNIQUE SUBSET OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-SPECIFIC CD4+ AND CD4-8- T-CELLS IN MICE AND HUMANS [J].

LANTZ, O ;

BENDELAC, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) :1097-1106

[28] RESTORATION OF EARLY THYMOCYTE DIFFERENTIATION IN T-CELL RECEPTOR BETA-CHAIN-DEFICIENT MUTANT MICE BY TRANSMEMBRANE SIGNALING THROUGH CD3-EPSILON [J].

LEVELT, CN ;

MOMBAERTS, P ;

IGLESIAS, A ;

TONEGAWA, S ;

EICHMANN, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :11401-11405

[29] BCL-2 IS UP-REGULATED AT THE CD4(+)CD8(+) STAGE DURING POSITIVE SELECTION AND PROMOTES THYMOCYTE DIFFERENTIATION AT SEVERAL CONTROL POINTS [J].

LINETTE, GP ;

GRUSBY, MJ ;

HEDRICK, SM ;

HANSEN, TH ;

GLIMCHER, LH ;

KORSMEYER, SJ .

IMMUNITY, 1994, 1 (03) :197-205

[30] HELPER T-CELLS WITHOUT CD4 - CONTROL OF LEISHMANIASIS IN CD4-DEFICIENT MICE [J].

LOCKSLEY, RM ;

REINER, SL ;

HATAM, F ;

LITTMAN, DR ;

KILLEEN, N .

SCIENCE, 1993, 261 (5127) :1448-1451

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