INDUCTION IN THE RAT HIPPOCAMPUS OF LONG-TERM POTENTIATION (LTP) AND LONG-TERM DEPRESSION (LTD) IN THE PRESENCE OF A NITRIC-OXIDE SYNTHASE INHIBITOR

被引：75

作者：

CUMMINGS, JA

NICOLA, SM

MALENKA, RC

机构：

[1] UNIV CALIF SAN FRANCISCO,LANGLEY PORTER PSYCHIAT INST,DEPT PSYCHIAT,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,LANGLEY PORTER PSYCHIAT INST,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,LANGLEY PORTER PSYCHIAT INST,GRAD PROGRAM NEUROSCI,SAN FRANCISCO,CA 94143

来源：

NEUROSCIENCE LETTERS | 1994年 / 176卷 / 01期

关键词：

LONG-TERM POTENTIATION; LONG-TERM DEPRESSION; NITRIC OXIDE; HIPPOCAMPUS; CA1; L-N-G-NITROARGININE;

D O I：

10.1016/0304-3940(94)90883-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several recent studies have suggested a critical role for nitric oxide (NO) production in hippocampal LTP and LTD. In this study we show that normal LTP and LTD can be induced in rat hippocampal slices incubated in the NO synthase inhibitor L-N-G-nitroarginine (NOArg) (100 mu M). A test of NMDA-stimulated cGMP production demonstrated that incubation of slices in 100 mu M NOArg effectively inhibited NO synthase. Our results suggest that NO synthase activity may not be required for the generation of LTP or LTD in CA1 of rat hippocampus.

引用

收藏

页码：110 / 114

页数：5

相关论文

共 28 条

[1] THE EFFECTS OF REPETITIVE LOW-FREQUENCY STIMULATION ON CONTROL AND POTENTIATED SYNAPTIC RESPONSES IN THE HIPPOCAMPUS [J].

BARRIONUEVO, G ;

SCHOTTLER, F ;

LYNCH, G .

LIFE SCIENCES, 1980, 27 (24) :2385-2391

[2] POSSIBLE INVOLVEMENT OF NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BOHME, GA ;

BON, C ;

STUTZMANN, JM ;

DOBLE, A ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 199 (03) :379-381

[3] A ROLE FOR NITRIC-OXIDE IN LONG-TERM POTENTIATION [J].

BON, C ;

BOHME, GA ;

DOBLE, A ;

STUTZMANN, JM ;

BLANCHARD, JC .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (05) :420-424

[4] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :682-685

[5] NITRIC-OXIDE SYNTHASE-INDEPENDENT LONG-TERM POTENTIATION IN AREA CA1 OF HIPPOCAMPUS [J].

CHETKOVICH, DM ;

KLANN, E ;

SWEATT, JD .

NEUROREPORT, 1993, 4 (07) :919-922

[6] HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF HIPPOCAMPUS AND EFFECTS OF N-METHYL-D-ASPARTATE RECEPTOR BLOCKADE [J].

DUDEK, SM ;

BEAR, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4363-4367

[7] NITRIC-OXIDE SYNTHASE - IRREVERSIBLE INHIBITION BY L-NG-NITROARGININE IN BRAIN INVITRO AND INVIVO [J].

DWYER, MA ;

BREDT, DS ;

SNYDER, SH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (03) :1136-1141

[8] NMDA RECEPTOR ACTIVATION IN RAT HIPPOCAMPUS INDUCES CYCLIC-GMP FORMATION THROUGH THE L-ARGININE NITRIC-OXIDE PATHWAY [J].

EAST, SJ ;

GARTHWAITE, J .

NEUROSCIENCE LETTERS, 1991, 123 (01) :17-19

[9] REVERSAL OF LONG-TERM POTENTIATION (DEPOTENTIATION) INDUCED BY TETANUS STIMULATION OF THE INPUT TO CA1 NEURONS OF GUINEA-PIG HIPPOCAMPAL SLICES [J].

FUJII, S ;

SAITO, K ;

MIYAKAWA, H ;

ITO, K ;

KATO, H .

BRAIN RESEARCH, 1991, 555 (01) :112-122

[10] ENDOTHELIUM-DERIVED RELAXING FACTOR RELEASE ON ACTIVATION OF NMDA RECEPTORS SUGGESTS ROLE AS INTERCELLULAR MESSENGER IN THE BRAIN [J].

GARTHWAITE, J ;

CHARLES, SL ;

CHESSWILLIAMS, R .

NATURE, 1988, 336 (6197) :385-388