HYBRID CYTOKINES AS HEMATOPOIETIC GROWTH-FACTORS

被引：20

作者：

WILLIAMS, DE ^{[1
]}

PARK, LS ^{[1
]}

BROXMEYER, HE ^{[1
]}

LU, L ^{[1
]}

机构：

[1] INDIANA UNIV,SCH MED,WALTHER ONCOL CTR,INDIANAPOLIS,IN 46202

来源：

INTERNATIONAL JOURNAL OF CELL CLONING | 1991年 / 9卷 / 06期

关键词：

GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-3; FUSION PROTEIN; CYTOKINES; HEMATOPOIESIS; MYELOSUPPRESSION;

D O I：

10.1002/stem.5530090604

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A large body of in vitro and in vivo data suggests that combinations of cytokines provide the most effective mechanism for stimulating multilineage acceleration of hematopoiesis. Creation of a granulocyte-macrophage colony-stimulating factor (GM-CSF)/interleukin 3 (IL-3) fusion protein has yielded a single therapeutic which has enhanced biological activity in comparison to the individual cytokines from which it is composed. In vivo studies with this fusion protein (PIXY321) suggest that it may provide a means to accelerate both neutrophil and platelet recovery in clinical settings in which hematopoiesis is suppressed. The biology of PIXY321 and the potential for other fusion proteins is discussed.

引用

页码：542 / 547

页数：6

共 27 条

[1] MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS [J].

ANDERSON, DM ;

LYMAN, SD ;

BAIRD, A ;

WIGNALL, JM ;

EISENMAN, J ;

RAUCH, C ;

MARCH, CJ ;

BOSWELL, HS ;

GIMPEL, SD ;

COSMAN, D ;

WILLIAMS, DE .

CELL, 1990, 63 (01) :235-243

[2]

BOT FJ, 1989, BLOOD, V73, P1157

[3] THE PRODUCTION OF MYELOID BLOOD-CELLS AND THEIR REGULATION DURING HEALTH AND DISEASE [J].

BROXMEYER, HE ;

WILLIAMS, DE .

CRC CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, 1988, 8 (03) :173-226

[4]

BROXMEYER HE, 1986, INT J CELL CLONING, V4, P378

[5]

BROXMEYER HE, 1991, BLOOD, V77, P2142

[6]

CANNISTRA SA, 1990, J BIOL CHEM, V265, P12656

[7] ENHANCED HEMATOPOIETIC ACTIVITY OF A HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR INTERLEUKIN-3 FUSION PROTEIN [J].

CURTIS, BM ;

WILLIAMS, DE ;

BROXMEYER, HE ;

DUNN, J ;

FARRAH, T ;

JEFFERY, E ;

CLEVENGER, W ;

DEROOS, P ;

MARTIN, U ;

FRIEND, D ;

CRAIG, V ;

GAYLE, R ;

PRICE, V ;

COSMAN, D ;

MARCH, CJ ;

PARK, LS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) :5809-5813

[8] THE EFFECT OF RECOMBINANT MAST-CELL GROWTH-FACTOR ON PURIFIED MURINE HEMATOPOIETIC STEM-CELLS [J].

DEVRIES, P ;

BRASEL, KA ;

EISENMAN, JR ;

ALPERT, AR ;

WILLIAMS, DE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1205-1211

[9]

ELLIOTT MJ, 1989, BLOOD, V74, P2349

[10]

FLETCHER MP, 1988, BLOOD, V71, P652

← 1 2 3 →