CLONING OF A RAB3 ISOTYPE PREDOMINATELY EXPRESSED IN ADIPOCYTES

被引：219

作者：

BALDINI, G ^{[1
]}

HOHL, T ^{[1
]}

LIN, HY ^{[1
]}

LODISH, HF ^{[1
]}

机构：

[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 11期

关键词：

D O I：

10.1073/pnas.89.11.5049

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated the cDNA for Rab3D, an additional member of the small molecular weight GTP-binding protein family. Rab3D message is abundant in mouse adipocytes. It is increased during differentiation of 3T3-L1 cells into adipocytes, temporally coincident with the appearance of the insulin-sensitive glucose transporter GLUT4. Rab3D is a close homolog of Rab3A, which is found on the cytoplasmic surface of neurosecretory vesicles and which may be involved in their regulated secretion. Since our previous work showed that in permeabilized adipocytes nonhydrolyzable GTP analogs mimic insulin in triggering exocytosis of GLUT4-containing vesicles, Rab3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes.

引用

页码：5049 / 5052

页数：4

共 30 条

[1]

BALDINI G, 1991, J BIOL CHEM, V266, P4037

[2] IDENTIFICATION OF A NOVEL GENE ENCODING AN INSULIN-RESPONSIVE GLUCOSE TRANSPORTER PROTEIN [J].