Yttrium-90 radioembolization of hepatic metastases from colorectal cancer

被引：30

作者：

Raval, Mihir ^{[1
]}

Bande, Dinesh ^{[2
,3
,4
]}

Pillai, Anil K. ^{[5
,6
]}

Blaszkowsky, Lawrence S. ^{[7
,8
,9
]}

Ganguli, Suvranu ^{[7
,10
,11
]}

Bee, Muhammad S. ^{[5
,12
]}

Kalva, Sanjeeva P. ^{[5
,6
]}

机构：

[1] Essentia Hlth, Dept Hosp Med, Fargo, ND USA

[2] Sanford Hlth, Dept Hosp Med, Fargo, ND USA

[3] Roger Maris Canc Ctr, Fargo, ND USA

[4] Univ North Dakota, Dept Internal Med, Fargo, ND USA

[5] Univ Texas Southwestern Med Ctr Dallas, Harold Simmons Canc Ctr, Dallas, TX 75390 USA

[6] Univ Texas Southwestern Med Ctr Dallas, Intervent Radiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

[7] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA

[8] Massachusetts Gen Hosp, Dept Hematol & Oncol, Boston, MA 02114 USA

[9] Harvard Med Sch, Dept Med, Boston, MA USA

[10] Massachusetts Gen Hosp, Dept Imaging, Sect Intervent Radiol, Boston, MA 02114 USA

[11] Harvard Med Sch, Dept Radiol, Boston, MA USA

[12] Univ Texas Southwestern Med Ctr Dallas, Dept Med, Div Hematol & Oncol, Dallas, TX 75390 USA

来源：

FRONTIERS IN ONCOLOGY | 2014年 / 4卷

关键词：

colorectal cancer; liver metastases; radioembolization; Yttrium-90; microspheres; Y-90; therapy; selective internal radiation therapy;

D O I：

10.3389/fonc.2014.00120

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes, and side effects of Y-90 microsphere therapy for metastatic CRC.

引用

页数：8

共 40 条

[11]

Cosimelli M., 2010, BRIT J CANCER, V27, P324, DOI DOI 10.1038/SJ.BJC.6605770

[12] Survival after hepatic resection in metastatic colorectal cancer - A population-based study [J].