ANTIGEN PRESENTATION BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I-B MOLECULES

被引：220

作者：

SHAWAR, SM ^{[1
]}

VYAS, JM ^{[1
]}

RODGERS, JR ^{[1
]}

RICH, RR ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 1994年 / 12卷

关键词：

CYTOTOXIC T LYMPHOCYTES; H-2M3; MHC EVOLUTION;

D O I：

10.1146/annurev.immunol.12.1.839

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Class I-b genes constitute the majority of MHC class I loci. These monomorphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes. Two main characteristics differentiate class I-b from class I-a molecules: limited polymorphism and lower cell surface expression. These distinguishing features suggest possible generalizations regarding the evolution and function of this class. Additionally, class I-b proteins tend to have shorter cytoplasmic domains or in some cases may be secreted or may substitute a lipid anchor for the transmembrane domain. Some are also expressed in a limited distribution of cells or tissues.

引用

页码：839 / 880

页数：42

共 177 条

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