NOSOCOMIAL SPREAD OF STAPHYLOCOCCUS-AUREUS SHOWING INTERMEDIATE RESISTANCE TO METHICILLIN

被引:7
作者
RICHARDS, J [1 ]
WILLIAMS, H [1 ]
WARNER, M [1 ]
JOHNSON, AP [1 ]
REITH, S [1 ]
WOODFORD, N [1 ]
MARPLES, RR [1 ]
GEORGE, RC [1 ]
机构
[1] CENT PUBL HLTH LAB,HOSP INFECT LAB,LONDON NW9 5HT,ENGLAND
关键词
STAPHYLOCOCCUS-AUREUS; INTERMEDIATE METHICILLIN RESISTANCE; NOSOCOMIAL OUTBREAK;
D O I
10.1016/0195-6701(93)90099-L
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
A nosocomial outbreak of infection and colonization involving six patients and caused by a strain of Staphylococcus aureus showing intermediate resistance to methicillin (MIC = 4-8 mg 1-1) is described. The outbreak was associated with skin-carriage of the epidemic strain by a nurse suffering from severe eczema. The reduced susceptibility of the outbreak strain to methicillin was associated with β-lactamase production. Elimination or inhibition of β-lactamase activity produced a two-fold decrease in methicillin MIC. There was no evidence for the presence of either penicillinbinding protein 2a or the corresponding mec gene, which mediate resistance in fully methicillin-resistant strains. © 1993.
引用
收藏
页码:91 / 96
页数:6
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