NOSOCOMIAL SPREAD OF STAPHYLOCOCCUS-AUREUS SHOWING INTERMEDIATE RESISTANCE TO METHICILLIN

被引：7

作者：

RICHARDS, J ^{[1
]}

WILLIAMS, H ^{[1
]}

WARNER, M ^{[1
]}

JOHNSON, AP ^{[1
]}

REITH, S ^{[1
]}

WOODFORD, N ^{[1
]}

MARPLES, RR ^{[1
]}

GEORGE, RC ^{[1
]}

机构：

[1] CENT PUBL HLTH LAB,HOSP INFECT LAB,LONDON NW9 5HT,ENGLAND

来源：

JOURNAL OF HOSPITAL INFECTION | 1993年 / 25卷 / 02期

关键词：

STAPHYLOCOCCUS-AUREUS; INTERMEDIATE METHICILLIN RESISTANCE; NOSOCOMIAL OUTBREAK;

D O I：

10.1016/0195-6701(93)90099-L

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A nosocomial outbreak of infection and colonization involving six patients and caused by a strain of Staphylococcus aureus showing intermediate resistance to methicillin (MIC = 4-8 mg 1-1) is described. The outbreak was associated with skin-carriage of the epidemic strain by a nurse suffering from severe eczema. The reduced susceptibility of the outbreak strain to methicillin was associated with β-lactamase production. Elimination or inhibition of β-lactamase activity produced a two-fold decrease in methicillin MIC. There was no evidence for the presence of either penicillinbinding protein 2a or the corresponding mec gene, which mediate resistance in fully methicillin-resistant strains. © 1993.

引用

页码：91 / 96

页数：6

共 17 条

[1]

BLAIR JE, 1961, B WORLD HEALTH ORGAN, V24, P771

[2] INTRINSIC RESISTANCE TO BETA-LACTAM ANTIBIOTICS IN STAPHYLOCOCCUS-AUREUS [J].

BROWN, DFJ ;

REYNOLDS, PE .

FEBS LETTERS, 1980, 122 (02) :275-278

[3] LOW-LEVEL METHICILLIN RESISTANCE IN STRAINS OF STAPHYLOCOCCUS-AUREUS [J].

CHAMBERS, HF ;

ARCHER, G ;

MATSUHASHI, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) :424-428

[4] A LABORATORY-CONFIRMED OUTBREAK OF RIFAMPICIN-METHICILLIN RESISTANT STAPHYLOCOCCUS-AUREUS (RMRSA) IN A NEWBORN NURSERY [J].

COOVADIA, YM ;

BHANA, RH ;

JOHNSON, AP ;

HAFFEJEE, I ;

MARPLES, RR .

JOURNAL OF HOSPITAL INFECTION, 1989, 14 (04) :303-312

[5]

DESAXE MJ, 1978, ZBL BAKT-INT J MED M, V241, P46

[6] HONG-KONG STRAINS OF METHICILLIN-RESISTANT AND METHICILLIN-SENSITIVE STAPHYLOCOCCUS-AUREUS HAVE SIMILAR VIRULENCE [J].

FRENCH, GL ;

CHENG, AFB ;

LING, JML ;

MO, P ;

DONNAN, S .

JOURNAL OF HOSPITAL INFECTION, 1990, 15 (02) :117-125

[7]

MASSIDDA O, 1992, FEMS MICROBIOL LETT, V92, P223

[8] THE ROLE OF BETA-LACTAMASE IN STAPHYLOCOCCAL RESISTANCE TO PENICILLINASE-RESISTANT PENICILLINS AND CEPHALOSPORINS [J].

MCDOUGAL, LK ;

THORNSBERRY, C .

JOURNAL OF CLINICAL MICROBIOLOGY, 1986, 23 (05) :832-839

[9] CHARACTERIZATION OF A WIDESPREAD STRAIN OF METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS-AUREUS ASSOCIATED WITH NOSOCOMIAL INFECTIONS [J].

MCMURRAY, LW ;

KERNODLE, DS ;

BARG, NL .

JOURNAL OF INFECTIOUS DISEASES, 1990, 162 (03) :759-762

[10] FURTHER CHARACTERIZATION OF BORDERLINE METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS AND ANALYSIS OF PENICILLIN-BINDING PROTEINS [J].

MONTANARI, MP ;

TONIN, E ;

BIAVASCO, F ;

VARALDO, PE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (05) :911-913

← 1 2 →