AN EFFICIENT AND CONCISE ENTRY TO (-)-4,5-DIHYDROXY-D-THREO-L-NORVALINE - FORMAL SYNTHESIS OF CLAVALANINE

被引：24

作者：

ARIZA, J ^{[1
]}

FONT, J ^{[1
]}

ORTUNO, RM ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,DEPT QUIM,UNITAT QUIM ORGAN,E-08193 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 17期

关键词：

D O I：

10.1016/0040-4039(91)85018-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title amino acid (2) has been synthesized for the first time in a seven-step sequence from D-ribonolactone, in 20% overall yield. Since the N-carbamoyl derivative of (2) in its gamma -lactone form has been used to prepare clavalanine, a formal total synthesis of this antibiotic is derived.

引用

页码：1979 / 1982

页数：4

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