Structure-Activity Relationship Study on the Ethyl p-Methoxycinnamate as an Anti-Inflammatory Agent

被引：8

作者：

Komala, Ismiarni ^{[1
]}

Supandi ^{[1
]}

Nurhasni ^{[2
]}

Betha, Ofa Suzanti ^{[1
]}

Putri, Eka ^{[1
]}

Mufidah, Syarifatul ^{[1
]}

Awaludin, Muhammad Fikry ^{[1
]}

Fahmi, Mida ^{[1
]}

Reza, Muhammad ^{[1
]}

Indriyani, Nurkhayati Putri ^{[1
]}

机构：

[1] Syarif Hidayatullah State Islamic Univ, Fac Med & Hlth Sci, Dept Pharm, Jl Kertamukti, Jakarta 15412, Indonesia

[2] Syarif Hidayatullah State Islamic Univ, Fac Sci & Technol, Dept Chem, Jl Ir H Juanda 95 Ciputat, Jakarta 15412, Indonesia

来源：

INDONESIAN JOURNAL OF CHEMISTRY | 2018年 / 18卷 / 01期

关键词：

Ethyl p-methoxycinnamate; anti-inflammatory; anti-denaturation; microwave assisted reaction; re-esterification;

D O I：

10.22146/ijc.26162

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ethyl p-methoxycinnamate (EPMC) (1) has been isolated as a major compound from the rhizome of Kaempferia galanga together with the other compound ethyl cinnamate (2). As reported in the literature, EPMC (1) exhibited a significant in vitro and in vivo anti-inflammatory activity. In this research, we have investigated the anti-inflammatory activity of compounds 1 and 2 by using anti-denaturation of heat bovine serum albumin (BSA) method. In order to analyze active sites that are responsible for the anti-inflammatory activity, therefore, it is necessary to conduct structural modification of EPMC (1). The structural modification was performed through re-esterification reaction by using conventional and assistance of the unmodified microwave oven. Evaluation of the results of the bioassay indicated that the ester and methoxy functional groups of EPMC (1) play an important role for the anti-inflammatory activity.

引用

页码：60 / 65

页数：6

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