CANDIDA-ALBICANS MENINGITIS IN A 27 WEEKS PREMATURE-INFANT TREATED WITH LIPOSOMAL AMPHOTERICIN-B (AMBISOME(R))

We report a case of Candida albicans meningitis in a neonate born after 27 weeks of gestation. To the best of our knowledge this is the first report of a premature infant with Candida-meningitis treated,vith liposomal amphotericin B (AmBisome(R)). The patient did not respond well to conventional Amphotericin B, but was successfully cured with AmBisome(R). Liposomal amphotericin B was well tolerated and the baby recovered with a postinfectious hydrocephalus which necessitated a permanent ventriculo-peritoneal shunt. Six months after the infection the baby appears to have a near-normal cerebral development.