A CONCISE SYNTHESIS OF (-)-DIHYDROPROTOLICHESTERINIC ACID VIA CONSECUTIVE STEREOCONTROLLED 1,4-CONJUGATE ADDITION AND SYN-ALDOL CONDENSATION-REACTIONS

被引：21

作者：

BANKS, MR ^{[1
]}

DAWSON, IM ^{[1
]}

GOSNEY, I ^{[1
]}

HODGSON, PKG ^{[1
]}

THORBURN, P ^{[1
]}

机构：

[1] BP INT LTD,CTR RES & ENGN,SUNBURY TW16 7LN,MIDDX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 20期

关键词：

D O I：

10.1016/0040-4039(95)00560-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Dihydroprotolichesterinic acid 1a is synthesised in 6 steps and 57% overall yield by a strategy employing the camphene-derived chiral auxiliary 2 to construct the three contiguous stereogenic centres in consecutive stereocontrolled 1,4-conjugate addition and syn-aldol reactions.

引用

页码：3567 / 3570

页数：4

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