Evidence for the osteosarcoma stem cell

被引：42

作者：

Gibbs, C. Parker, Jr. ^{[1
]}

Levings, Padraic P. ^{[1
]}

Ghivizzani, Steven C. ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Orthopaed Surg, 3450 Hull Rd, Gainesville, FL 32607 USA

来源：

CURRENT ORTHOPAEDIC PRACTICE | 2011年 / 22卷 / 04期

关键词：

osteosarcoma; ''cancer stem cell; heterogeneity; tumorigenic;

D O I：

10.1097/BCO.0b013e318221aee8

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Osteosarcoma is a highly malignant bone tumor of children and young adults. Cytotoxic chemotherapy combined with aggressive surgery only has a 60% survival rate. Historically, chemotherapy has been developed assuming that all cells within a particular cancer are clonal and near identical. Appreciating the now apparent functional heterogeneity of osteosarcoma cells within and between individual tumors will likely be critical in developing much needed novel effective therapies. The foundation for this heterogeneity may lie in the so called ''cancer stem cell'' or tumorigenic cell of origin. In this brief review, we examine the evidence for the existence of this cell and its potential importance for future therapies.

引用

页码：322 / 326

页数：5

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