Obstructive sleep apnea and bone mineral density in obese patients

被引：38

作者：

Mariani, Stefania ^{[1
]}

Fiore, Daniela ^{[1
]}

Varone, Laura ^{[2
]}

Basciani, Sabrina ^{[1
]}

Persichetti, Agnese ^{[1
]}

Watanabe, Mikiko ^{[1
]}

Saponara, Maurizio ^{[3
]}

Spera, Giovanni ^{[1
]}

Moretti, Costanzo ^{[4
]}

Gnessi, Lucio ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Expt Med, Sect Med Physiopathol & Endocrinol, Rome, Italy

[2] Sapienza Univ Rome, Dept Environm Biol, Rome, Italy

[3] Sapienza Univ Rome, Dept Otolaryngol Audiol & Phonat, Rome, Italy

[4] Univ TorVergata, Fatebenefratelli Hosp, Dept Syst Med, Div Endocrinol,Sect Reproduct Endocrinol, Rome, Italy

来源：

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2012年 / 5卷

关键词：

obesity; polysomnography; metabolic syndrome;

D O I：

10.2147/DMSO.S37761

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: Obesity and its co-morbidities may adversely affect bone mineral density (BMD). Obstructive sleep apnea (OSA) is a major complication of obesity. To date, the effects of OSA on BMD in obese patients have been poorly studied. Objective: To examine whether the severity of OSA independently correlates with BMD in obese patients. Methods: One hundred and fifteen obese subjects with OSA (Apnea/Hypopnea Index [AHI] >= 5 events per hour) were included in the study. BMD was measured at lumbar spine, total hip, and femoral neck by dual energy X-ray absorptiometry. Body mass index, lean mass, and representative measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, HDL-cholesterol, triglycerides) and inflammation (ESR, CRP, fibrinogen) were also evaluated. Results: BMD did not differ among obese individuals regardless of OSA severity. Correlation coefficient analysis for all the covariates showed a lack of association between AHI and BMD that was strongly influenced by age and weight. Conclusion: Our study does not support an independent association between AHI and BMD in obese patients. Controlled studies involving a greater number of patients are warranted.

引用

页码：395 / 401

页数：7