PROOF OF THE BIS(OXAZOLIDINE)METHANE STRUCTURE FOR THE NOREPHEDRINE-FORMALDEHYDE CONDENSATION PRODUCT

被引：3

作者：

AITKEN, DJ ^{[1
]}

CHIARONI, A ^{[1
]}

RICHE, C ^{[1
]}

HUSSON, HP ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,CRISTALLOCHIM LAB,F-91198 GIF SUR YVETTE,FRANCE

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 7-8期

关键词：

NOREPHEDRINE; BIS(OXAZOLIDINE)METHANE;

D O I：

10.1002/ardp.19953280713

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The norephedrine-formaldehyde condensation product, a potential prodrug, was shown to have a bis(oxazolidine)methane structure by an X-ray crystallography study.

引用

页码：629 / 630

页数：2

共 6 条

[1] IDENTIFICATION, SYNTHESIS AND CONFORMATIONAL STUDY OF A CN(R,S) SYNTHON BY-PRODUCT - (5R,10R)-5,10-DIPHENYL-1,6-DIAZA-3,8-DIOXABICYCLO[4.4.1]UNDECANE [J].

AITKEN, DJ ;

GUILLAUME, D ;

HUSSON, HP ;

CHIARONI, A ;

RICHE, C .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (03) :705-709

[2]

ENGEL J, 1982, Patent No. 3143950

[3]

LASAGNA L, 1988, PHENYLPROPANOLAMINE

[4]

Sheldrick G.M., 1986, SHELXS86 PROGRAM SOL

[5]

SHELDRICK GM, 1976, SHELX PROGRAM CRYSTA

[6]

WALKER R, 1992, Drugs of the Future, V17, P215

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